Search results for "Alcohol exposure"
showing 2 items of 2 documents
Mechanisms of protein expression in the rat optic nerve: Modifications by alcohol exposure
2005
espanolObjetivos: Nuestros trabajos previos han demostrado que el consumo abusivo de etanol durante la gestacion induce retraso en el desarrollo y alteraciones estructurales en los ojos y en la vision (Pinazo-Duran et al., Teratology 93; Eur J Ophthalmol 97; Stromland and Pinazo-Duran, Teratology 94; Alcohol Alcoholism 02). Nos proponemos estudiar a un nivel celular y molecular si el etanol modifica la expresion de proteinas marcadoras del desarrollo glial durante los estadios pre- y postnatal de la rata, que puedan contribuir a la dismorfogenesis del nervio optico. Metodo: Para estudiar las acciones del etanol sobre el desarrollo del nervio optico de ratas sometidas a un proceso de alc…
Comprehensive Genomic and Transcriptomic Analysis of Three Synchronous Primary Tumours and a Recurrence from a Head and Neck Cancer Patient
2021
Synchronous primary malignancies occur in a small proportion of head and neck squamous cell carcinoma (HNSCC) patients. Here, we analysed three synchronous primaries and a recurrence from one patient by comparing the genomic and transcriptomic profiles among the tumour samples and determining the recurrence origin. We found remarkable levels of heterogeneity among the primary tumours, and through the patterns of shared mutations, we traced the origin of the recurrence. Interestingly, the patient carried germline variants that might have predisposed him to carcinogenesis, together with a history of alcohol and tobacco consumption. The mutational signature analysis confirmed the impact of alc…